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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin

Fig. 3

PIK3CA H1047R results in upregulation of RSAD2. A, Ranking of DEG in PIK3CAH1047R vs. control dataset (n = 30) based on fold-change value. Gene ranked first is labeled in red. B, Western blot of 12Z cell expression of Viperin, phospho-AKT, AKT and β-Actin following siRSAD2, PIK3CAH1047R and insulin treatment. Western blots are representative of n = 2 independent experiments. Uncropped images are available in Supplemental Fig. 2. C, Volcano plot of DGE in siRSAD2 vs. control, FDR < 0.001. Significant genes are labeled in red. D, GOBP enrichment among genes differentially expressed in siRSAD2 vs. control dataset

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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