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  1. Ovarian cancer is the leading cause of death in patients with gynecologic cancer, and circular RNAs (circRNAs) are involved in cancer progression. However, there are limited studies on the roles of circRNAs in...

    Authors: Yuping Du, Xin Liu, Song Zhang, Shuo Chen, Xue Guan, Qianhui Li, Xi Chen and Yang Zhao

    Citation: Reproductive Biology and Endocrinology 2021 19:176

    Content type: Research

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  2. Immune dysfunction is one of the mechanisms to promote polycystic ovary syndrome (PCOS). Various immune cells have been reported to be involved in the development of PCOS. Meanwhile, the disturbance of metabol...

    Authors: Mengting Zhu, Yuping Xu, Caihua Li, Zhimin Lu, Kaihuan Bi, Kangxia Wang, Peipei Guo, Huanhuan Jiang and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2021 19:175

    Content type: Research

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  3. Assisted reproductive technology (ART) insurance mandates promote more selective utilization of ART clinic resources including intracytoplasmic sperm injection (ICSI). Our objective was to examine whether ICSI...

    Authors: Pavel Zagadailov, Kyung S. Cho and David B. Seifer

    Citation: Reproductive Biology and Endocrinology 2021 19:174

    Content type: Research

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  4. Bone morphogenetic protein 2 (BMP2), growth differentiation factor 8 (GDF8) and their functional receptors are expressed in human ovarian follicles, and these two intrafollicular factors play essential roles i...

    Authors: Xiaoyan Luo, Hsun-Ming Chang, Yuyin Yi, Yingpu Sun and Peter C. K. Leung

    Citation: Reproductive Biology and Endocrinology 2021 19:173

    Content type: Research

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  5. Information regarding the influence of cytoplasmic events during fertilisation on the clinical outcome remains limited. The cytoplasmic halo is one of these events. A previous study that used time-lapse techno...

    Authors: Kenji Ezoe, Tetsuya Miki, Tadashi Okimura, Kazuo Uchiyama, Akiko Yabuuchi, Tamotsu Kobayashi and Keiichi Kato

    Citation: Reproductive Biology and Endocrinology 2021 19:172

    Content type: Research

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  6. With the increased use of assisted reproductive technology (ART), assessing the potential health risks of children conceived on ART important to public health. Most research in this area has focused on the eff...

    Authors: Xin Xu, Han Wu, Yuehong Bian, Linlin Cui, Yuanyuan Man, Zhao Wang, Xin Zhang, Changming Zhang and Ling Geng

    Citation: Reproductive Biology and Endocrinology 2021 19:171

    Content type: Research

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  7. Polycystic ovary syndrome (PCOS) is an endocrine-related follicular developmental disorder that affects 50 %-70 % of reproductive-aged women diagnosed with ovulation-related infertility. Abnormal proliferation...

    Authors: Yi-xuan Wu, Yan-shan Lin, Si-chen Li, Xi Yao, Mingwei Cheng, Lin Zhu and Hai-ying Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:170

    Content type: Research

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  8. Citation: Reproductive Biology and Endocrinology 2021 19:169

    Content type: Correction

    Published on:

    The original article was published in Reproductive Biology and Endocrinology 2021 19:137

  9. Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or m...

    Authors: Weiguo He, Huiqing Liu, Linlin Hu, Yaohui Wang, Lane Huang, Aihong Liang, Xuan Wang, Qing Zhang, Yi Chen, Yi Cao, Suyun Li, Junli Wang and Xiaocan Lei

    Citation: Reproductive Biology and Endocrinology 2021 19:168

    Content type: Research

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  10. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women at childbearing age. Several circular RNAs (circRNAs) have been demonstrated to be involved in PCOS. In this study, we aime...

    Authors: Lishuang Xu, Fang Xiong, Yinyang Bai, Juxia Xiao, Yun Zhang, Jie Chen and Qiuping Li

    Citation: Reproductive Biology and Endocrinology 2021 19:167

    Content type: Research

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  11. Maternal metabolic disorders are linked to reduced metabolic health and oocyte quality. Obese women are advised to lose weight before conception to increase pregnancy chances. However, as human studies show no...

    Authors: Anouk Smits, Waleed F. A. Marei, Diane De Neubourg and Jo L. M. R. Leroy

    Citation: Reproductive Biology and Endocrinology 2021 19:166

    Content type: Research

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  12. Progesterone supplementation is widely performed in women with threatened miscarriage or a history of recurrent miscarriage; however, the effects of early progesterone supplementation on pregnancy-related comp...

    Authors: Hanglin Wu, Songying Zhang, Xiaona Lin, Jing He, Shasha Wang and Ping Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:165

    Content type: Review

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  13. Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precurso...

    Authors: Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser and Régine P. M. Steegers-Theunissen

    Citation: Reproductive Biology and Endocrinology 2021 19:164

    Content type: Research

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  14. The application of artificial oocyte activation (AOA) after intracytoplasmic sperm injection (ICSI) is successful in mitigating fertilization failure problems in assisted reproductive technology (ART). Neverth...

    Authors: Mingru Yin, Weina Yu, Wenzhi Li, Qianqian Zhu, Hui Long, Pengcheng Kong and Qifeng Lyu

    Citation: Reproductive Biology and Endocrinology 2021 19:163

    Content type: Research

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  15. Endometriosis, the presence of active endometrial tissue outside the lining membrane of the uterine cavity, is a common disease in women of childbearing age. The ectopic endometrium has some characteristics of...

    Authors: Liya Shi, Xue Xue, Hui Tian, Hongjuan Ye, Hui Wang, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen and Lihua Sun

    Citation: Reproductive Biology and Endocrinology 2021 19:161

    Content type: Research

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  16. Infertility associated with endometriosis can be explained by several non-exclusive mechanisms. The oocyte plays a crucial role in determining embryonic competence and this is particularly relevant for in vitr...

    Authors: Camille Robin, Audrey Uk, Christine Decanter, Hélène Behal, Pierre Collinet, Chrystèle Rubod, Anne-Laure Barbotin and Geoffroy Robin

    Citation: Reproductive Biology and Endocrinology 2021 19:160

    Content type: Research

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  17. Azoospermic patients have benefited from both epididymal and testicular spermatozoa intracytoplasmic sperm injection (ICSI) treatment and lasers have been used to identify viable, immotile spermatozoa before t...

    Authors: Huanhua Chen, Caizhu Wang, Hong Zhou, Jinhui Shu, Xianyou Gan, Kongrong Xu, Zhulian Wu, Xihe Deng, Guiting Huang and Ruoyun Lin

    Citation: Reproductive Biology and Endocrinology 2021 19:159

    Content type: Research

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  18. Synchronization of follicles is key to improving ovulation stimulation with the gonadotropin-releasing hormone (GnRH) antagonist protocol. GnRH antagonist administration in the early follicular phase can quick...

    Authors: Yisheng Zhang, Liling Liu, Jie Qin, Hongyi Huang, Lintao Xue, Shikai Wang and Weihong Tan

    Citation: Reproductive Biology and Endocrinology 2021 19:158

    Content type: Research

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  19. Infertility, an important source of stress, could affect sexual life. Extensive studies suggest that the incidence of sexual dysfunction is highly prevalent in infertile women. As the duration of infertility i...

    Authors: Meng Dong, Xiaoyan Xu, Yining Li, Yixian Wang, Zhuo Jin and Jichun Tan

    Citation: Reproductive Biology and Endocrinology 2021 19:157

    Content type: Research

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  20. Human papillomavirus (HPV) has been shown to adversely affect human reproduction. We aimed to evaluate the prevalence of human papillomavirus (HPV) infection in men and its correlation with semen parameters an...

    Authors: Hana Jaworek, Vladimira Koudelakova, Ivana Oborna, Blazena Zborilova, Jana Brezinova, Dagmar Ruzickova, Jana Vrbkova, Pavla Kourilova and Marian Hajduch

    Citation: Reproductive Biology and Endocrinology 2021 19:156

    Content type: Research

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  21. Embryo cryopreservation is a widely used technique in infertility management and today is an essential part of assisted reproductive technology (ART). In some cases, re-vitrification can be applied to good qua...

    Authors: Maryam Daneshvar, Mansoureh Movahedin, Mohammad Salehi and Mehrdad Noruzinia

    Citation: Reproductive Biology and Endocrinology 2021 19:155

    Content type: Research

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  22. To investigate whether the endometrial thickness change ratio from the progesterone administration day to the blastocyst transfer day is associated with pregnancy outcomes in a single frozen-thawed euploid bla...

    Authors: Ziqi Jin, Jingdi Li, EnTong Yang, Hao Shi, Zhiqin Bu, Wenbin Niu, Fang Wang, Mingzhu Huo, Hui Song and YiLe Zhang

    Citation: Reproductive Biology and Endocrinology 2021 19:154

    Content type: Research

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  23. Gynecologic oncologists should be aware of the option of conception through IVF/PGT-M for families with high BRCA related morbidity or mortality. Our objective was to investigate the cost-effectiveness of prei...

    Authors: Nadav Michaan, Moshe Leshno, Yoni Cohen, Tamar Safra, Shira Peleg-Hasson, Ido Laskov and Dan Grisaru

    Citation: Reproductive Biology and Endocrinology 2021 19:153

    Content type: Research

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  24. There are two major management approach for cornual heterotopic pregnancy, transvaginal cornual embryo reduction with ultrasound guidance, or laparoscopic cornual resection. This no consensus on the optimal ma...

    Authors: Sichen Li, Mingzhu Cao, Hanyan Liu, Yuxia He and Jianqiao Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:152

    Content type: Research

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  25. There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertilit...

    Authors: Mireia González-Comadran, Bénédicte Jacquemin, Marta Cirach, Rafael Lafuente, Thomas Cole-Hunter, Mark Nieuwenhuijsen, Mario Brassesco, Buenaventura Coroleu and Miguel Angel Checa

    Citation: Reproductive Biology and Endocrinology 2021 19:151

    Content type: Research

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  26. Advanced glycation end-products (AGE), which accumulate with insulin resistance and aging, impair folliculogenesis and may decrease endometrial receptivity. Hishi (Trapa bispinosa Roxb.) extract, a safe herbal me...

    Authors: Masao Jinno, Ryoji Nagai, Masayoshi Takeuchi, Aiko Watanabe, Koji Teruya, Hikari Sugawa, Naohisa Hatakeyama and Yuichi Jinno

    Citation: Reproductive Biology and Endocrinology 2021 19:149

    Content type: Research

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  27. Recently, human infertility incidence is increasing in obese women causing it to become an emerging global health challenge requiring improved treatment. There is extensive evidence that obesity caused female ...

    Authors: Xiuxiu Gao, Yangyang Li, Zhuoyao Ma, Jia Jing, Zhengqing Zhang, Yue Liu and Zhide Ding

    Citation: Reproductive Biology and Endocrinology 2021 19:148

    Content type: Research

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  28. Polycystic ovary syndrome (PCOS), as the most common endocrine disorder in reproductive-aged women, is characterized by oxidative stress and ovarian tissue inflammation. Green tea extract (GTE) potentially pos...

    Authors: Vahid Maleki, Ehsaneh Taheri, Parisa Varshosaz, Fatemeh Pourteymour Fard Tabrizi, Jalal Moludi, Hamed Jafari-Vayghan, Mahdi Shadnoush, Seyed Hossein Yahyazadeh Jabbari, Mehri Seifoleslami and Mohammad Alizadeh

    Citation: Reproductive Biology and Endocrinology 2021 19:147

    Content type: Review

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  29. Phthalates such as di (2-ethylhexyl) phthalate (DEHP) are well known exogenous substances, disrupting reproductive system function and structure. The current research demonstrated the effect of ellagic acid (E...

    Authors: Azam Hosseinzadeh, Saeed Mehrzadi, Amir Siahpoosh, Zahra Basir, Nosrat Bahrami and Mehdi Goudarzi

    Citation: Reproductive Biology and Endocrinology 2021 19:146

    Content type: Research

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  30. Overweight and obesity affect millions of people globally, which has also serious implications for reproduction. For example, treatment outcomes after in vitro fertilisation (IVF) are worse in women with a hig...

    Authors: Linette van Duijn, Melek Rousian, Jeffrey Hoek, Sten P. Willemsen, Eva S. van Marion, Joop S. E. Laven, Esther B. Baart and Régine P. M. Steegers-Theunissen

    Citation: Reproductive Biology and Endocrinology 2021 19:145

    Content type: Research

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  31. In mammals, germline development undergoes dramatic morphological and molecular changes and is epigenetically subject to intricate yet exquisite regulation. Which epigenetic players and how they participate in...

    Authors: Xue Jiang, Xiaoli Zhu, Yu Cheng, Muhammad Azhar, Xuemei Xing, Wenqing Li, Yuzhu Cao, Qinghua Shi and Jianqiang Bao

    Citation: Reproductive Biology and Endocrinology 2021 19:144

    Content type: Short communication

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  32. Diminished ovarian reserve (DOR) refers to a decrease in the number and quality of oocytes in the ovary, which results in a lack of sex hormones and a decline of fertility in women. DOR can potentially progres...

    Authors: Chengcheng Liang, Xiaole Zhang, Cong Qi, Hui Hu, Qinhua Zhang, Xiuxian Zhu and Yonglun Fu

    Citation: Reproductive Biology and Endocrinology 2021 19:143

    Content type: Research

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  33. Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was c...

    Authors: Jianeng Zhang, Chong Wang, Huanhuan Zhang and Yan Zhou

    Citation: Reproductive Biology and Endocrinology 2021 19:142

    Content type: Research

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  34. Caudal Type Homeobox 2 (CDX2) is a key regulator of trophectoderm formation and maintenance in preimplantation embryos. We previously demonstrated that supplementation of exogenous follistatin, during in vitro...

    Authors: Mohamed Ashry, Chunyan Yang, Sandeep K. Rajput, Joseph K. Folger, Jason G. Knott and George W. Smith

    Citation: Reproductive Biology and Endocrinology 2021 19:141

    Content type: Short communication

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  35. There has been increasing interest in the relationship between body mass index(BMI) and pregnancy outcomes, especially in women undergoing frozen embryo transfer(FET). Several observational studies have been p...

    Authors: Jiaqi Yang, Yichen He, Yiqing Wu, Dan Zhang and Hefeng Huang

    Citation: Reproductive Biology and Endocrinology 2021 19:140

    Content type: Review

    Published on:

  36. Granulosa cells (GCs) in cumulus oophorus highly express follicle stimulating hormone receptor (FSHR), which is the most important mediator of both estradiol synthesis and oocyte maturation. Obese women have e...

    Authors: Nan Wang, Chenchen Si, Lan Xia, Xian Wu, Sheng Zhao, Huihui Xu, Zhide Ding and Zhihong Niu

    Citation: Reproductive Biology and Endocrinology 2021 19:139

    Content type: Research

    Published on:

  37. Poor endometrial receptivity is a major factor that leads to recurrent implantation failure. However, the traditional method cannot accurately evaluate endometrial receptivity. Various studies have indicated t...

    Authors: Yuhao Zhao, Dongmei He, Hong Zeng, Jiefeng Luo, Shuang Yang, Jingjing Chen, Raed K. Abdullah and Nenghui Liu

    Citation: Reproductive Biology and Endocrinology 2021 19:138

    Content type: Research

    Published on:

  38. Poor ovarian response (POR) is among the common findings in infertile women with no significant underlying condition. The aim of this study was to investigate the intra-ovarian potential of platelet-rich plasm...

    Authors: Marzieh Farimani, Arash Nazari, Shahrzad Mohammadi and Roghayeh Anvari Aliabad

    Citation: Reproductive Biology and Endocrinology 2021 19:137

    Content type: Research

    Published on:

    The Correction to this article has been published in Reproductive Biology and Endocrinology 2021 19:169

  39. Infertility is a common complication in obese men. Oxidative stress and testicular apoptosis play critical roles in obesity-induced spermatogenesis dysfunction. It has been reported that irisin, an exercise-in...

    Authors: Yang Mu, Huang-Guan Dai, Ling-Bo Luo and Jing Yang

    Citation: Reproductive Biology and Endocrinology 2021 19:135

    Content type: Research

    Published on:

  40. Insufficient migration and invasion during trophoblast epithelial-mesenchymal transition (EMT) results in the occurrence and development of preeclampsia (PE), and our previous study has screened 52 miRNAs, who...

    Authors: Meiyuan Jin, Shouying Xu, Jiayong Li, Yingyu Yao and Chao Tang

    Citation: Reproductive Biology and Endocrinology 2021 19:134

    Content type: Research

    Published on:

  41. In-vitro-grow (IVG) of preantral follicles is essential for female fertility preservation, while practical approach for improvement is far from being explored. Studies have indicated that neurotrophin-4 (NT-4)...

    Authors: Yingchun Guo, Peigen Chen, Tingting Li, Lei Jia, Yi Zhou, Jiana Huang, Xiaoyan Liang, Chuanchuan Zhou and Cong Fang

    Citation: Reproductive Biology and Endocrinology 2021 19:133

    Content type: Research

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  42. Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unkno...

    Authors: Fereshteh Esfandiari, Fereshteh Chitsazian, Masoumeh Golestan Jahromi, Raha Favaedi, Masood Bazrgar, Reza Aflatoonian, Parvaneh Afsharian, Abbas Aflatoonian and Maryam Shahhoseini

    Citation: Reproductive Biology and Endocrinology 2021 19:132

    Content type: Research

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  43. The optimal time at which to perform a frozen-thawed embryo transfer (FET) following a failed in-vitro fertilization-embryo transfer (IVF-ET) attempt remains elusive to most reproductive experts. Physicians often...

    Authors: Jing-Yan Song, Feng-Yi Dong, Li Li, Xing-Xing Zhang, Ai-Juan Wang, Yi Zhang, Dan-Dan Gao, Ji-Mei Xiao and Zhen-Gao Sun

    Citation: Reproductive Biology and Endocrinology 2021 19:131

    Content type: Research

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  44. To investigate recommendations for appropriate gestational weight gain (GWG) of Chinese females.

    Authors: Yin Sun, Zhongzhou Shen, Yongle Zhan, Yawen Wang, Shuai Ma, Suhan Zhang, Juntao Liu, Sansan Wu, Yahui Feng, Yunli Chen, Shuya Cai, Yingjie Shi, Liangkun Ma and Yu Jiang

    Citation: Reproductive Biology and Endocrinology 2021 19:130

    Content type: Research

    Published on:

  45. Non-obstructive azoospermia (NOA) is the most severe form of male infertility; more than half of the NOA patients are idiopathic. Although many NOA risk genes have been detected, the genetic factors for NOA in...

    Authors: Dongdong Tang, Mingrong Lv, Yang Gao, Huiru Cheng, Kuokuo Li, Chuan Xu, Hao Geng, Guanjian Li, Qunshan Shen, Chao Wang, Xiaojin He and Yunxia Cao

    Citation: Reproductive Biology and Endocrinology 2021 19:129

    Content type: Research

    Published on:

  46. Anticentromere antibody (ACA) is a member of the antinuclear antibody spectrum (ANAs) which has been speculated to be associated with subfertility. Thus, the present study aimed to investigate the induction of...

    Authors: Hanyan Liu, Yufen Zhang, Haiying Liu, Qing Huang and Ying Ying

    Citation: Reproductive Biology and Endocrinology 2021 19:127

    Content type: Research

    Published on:

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