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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Seminal plasma extracellular vesicles tRF-Val-AAC-010 can serve as a predictive factor of successful microdissection testicular sperm extraction in patients with non-obstructive azoospermia

Fig. 4

tRF-Val-AAC-010 is biomarker of successful sperm retrieval in testicular tissue with non-obstructive azoospermia. A Validation of the expression of tRF-Val-AAC-010 and tRF-Pro-AGG-003 by qRT-PCR from 23 NOA-(Sp-) samples and 18 NOA-(Sp+) samples. Normalized expression levels relative to the U6 gene. B ROC curve of tRF-Val-AAC-010, tRF-Pro-AGG-003, testicular volume and FSH level for predictive classification of NOA-(Sp+) patients and NOA-(Sp-) patients. C tRF-Val-AAC-010 and its predicted target mRNAs (Nodes in red diamond is tRF-Val-AAC-010; nodes in circle color are predicted target mRNAs for the tRF-Val-AAC-010; nodes of the blue circles are genes that have been reported to be involved in spermatogenesis). D The most significant biological process GO terms for the 13 target genes of tRF-Val-AAC-010. Data shown as the means (10–90% percentile). Statistical analysis was performed by using two-tailed unequal variant Student’s t-test (*** P-value < 0.001)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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