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Table 1 Baseline demographic and clinical characteristics of patients

From: Endometrial thickness is an independent risk factor of hypertensive disorders of pregnancy: a retrospective study of 13,458 patients in frozen-thawed embryo transfers

Variables

Normal EMT

Thin EMT

Thick EMT

P-values

All

Normal vs thin

Normal vs Thick

Thin vs Thick

Number

11,562

827

1069

    

Maternal age (y)

30.41 (3.97)

31.05 (4.11)

30.51 (3.94)

<  0.001

<  0.001

0.473

0.003

Maternal BMI (kg/m2)

23.20 (3.51)

22.87 (3.34)

23.25 (3.42)

0.027

0.010

0.611

0.018

Paternal age (y)

31.12 (4.59)

31.76 (5.05)

30.87 (4.49)

<  0.001

<  0.001

0.096

<  0.001

Paternal BMI (kg/m2)

25.81 (4.08)

25.88 (4.19)

26.12 (4.14)

0.058

0.618

0.018

0.214

Type of infertility, n (%)

 Primary

6365 (55.05)

302 (36.52)

665 (62.21)

    

 Secondary

5197 (44.95)

525 (63.48)

404 (37.79)

<  0.001

<  0.001

<  0.001

<  0.001

PCOS, n (%)

2034 (17.59)

179 (21.64)

97 (9.07)

<  0.001

<  0.001

<  0.001

<  0.001

Intrauterine adhesion, n (%)

214 (1.85)

85 (10.28)

4 (0.37)

<  0.001

<  0.001

0.002

<  0.001

Childbirth experience, n (%)

 Nullipara

8127 (70.29)

551 (66.63)

726 (67.91)

    

 Pluripara

3435 (29.71)

276 (33.37)

343 (32.09)

0.029

0.087

0.336

0.999

Number of abortions, n (%)

 0

7545 (65.26)

374 (45.22)

749 (70.07)

    

 1

2825 (24.43)

263 (31.80)

220 (20.58)

    

  ≥ 2

1192 (10.31)

190 (22.97)

100 (9.35)

<  0.001

<  0.001

0.017

<  0.001

Development of embryo, n (%)

 Blastocyst

11,367 (98.31)

820 (99.15)

1049 (98.13)

    

 Cleavage-stage

195 (1.69)

7 (0.85)

20 (1.87)

0.157

0.267

0.999

0.284

Mean EMT (cm)

0.97 (0.12)

0.72 (0.05)

1.32 (0.08)

<  0.001

<  0.001

<  0.001

<  0.001

Delivery model, n (%)

 Spontaneous labor

3567 (30.85)

210 (25.39)

381 (35.64)

    

 Cesarean labor

7995 (69.15)

617 (74.61)

688 (64.36)

<  0.001

0.003

0.004

<  0.001

Mean neonatal weight (kg)

3.46 (0.51)

3.38 (0.56)

3.45 (0.5)

<  0.001

<  0.001

0.587

0.005

Outcome, n (%)

 Full-term birth

10,825 (93.63)

758 (91.66)

1007 (94.20)

    

 Pre-term birth

704 (6.09)

66 (7.98)

59 (5.52)

    

 Post-term birth

33 (0.29)

3 (0.36)

3 (0.28)

0.215

0.256

0.999

0.285

HDP, n (%)

531 (4.59)

66 (7.98)

56 (5.24)

<  0.001

<  0.001

0.999

0.061

Number of embryos, n (%)

 1

10,652 (92.13)

774 (93.59)

1000 (93.55)

    

  > 1

910 (7.87)

53 (6.41)

69 (6.45)

0.093

0.454

0.343

0.999

History of cesarean delivery, n (%)

1724 (14.91)

127 (15.36)

155 (14.50)

0.873

0.999

0.999

0.999

Endometrial preparation regimen, n (%)

 Natural

7190 (62.19)

350 (42.32)

916 (85.69)

    

 Artificial

4372 (37.81)

477 (57.68)

153 (14.31)

<  0.001

<  0.001

<  0.001

<  0.001

GDM, n (%)

836 (7.23)

71 (8.59)

84 (7.86)

0.288

0.507

0.999

0.999

Systolic blood pressure (mmHg)

116.54 (11.89)

115.46 (11.54)

117.09 (11.60)

0.011

0.012

0.146

0.003

Diastolic blood pressure (mmHg)

69.66 (8.68)

68.94 (8.41)

70.12 (8.87)

0.013

0.020

0.102

0.003

  1. Values are presented as mean ± standard deviation or n (%)
  2. The between-groups differences in continuous variables are analyzed by LSD post-hoc multiple comparison
  3. BMI Body mass index, EMT Endometrial thickness, PCOS Polycystic ovary syndrome, HDP Hypertensive disorders of pregnancy, GDM Gestational diabetes mellitus
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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