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Table 2 Longitudinal study of utero-placental (vascular) development trajectories and placental weight stratified by corpus luteum number

From: Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

 

7 weeks

9 weeks

11 weeks

13 weeks

22 weeks

32 weeks

At birth

GA (days)

0 CL

52 [51;54]

67 [65;67]

81 [79;81]

96 [94;97]

160 [157;161]

227 [226;230]

273 [271;280]

1 CL

51 [50;54]

66 [65;67]

79 [78;82]

93 [92;94]

157 [155;159]

226 [224;228]

273 [265;279]

> 1 CL

51 [50;54]

66 [65;67]

79 [78;82]

93 [92;94]

157 [155;159]

226 [224;228]

275 [269;284]

PV (cm3)

0 CL

12.8 ± 8.7

43.7 ± 15.1

94.4 ± 8.8

    

1 CL

17.8 ± 10.7

45.5 ± 16.4

98.0 ± 33.8

    

> 1 CL

15.2 ± 7.7

49.5 ± 21.8

102.1 ± 34.7

    

uPVV (cm3)

0 CL

5.1 ± 7.3

11.2 ± 4.9

19.4 ± 8.6

    

1 CL

3.7 ± 3.3

9.9 ± 7.0

19.0 ± 10.5

    

> 1 CL

2.7 ± 2.7*3

10.4 ± 10.1

17.4 ± 14.2

    

UtA RI

0 CL

0.82 ± 0.06

0.75 ± 0.07

0.70 ± 0.15

0.59 ± 0.14**1,2

0.39 ± 0.05***1,2

0.44 ± 0.08

 

1 CL

0.86 ± 0.08

0.81 ± 0.09

0.76 ± 0.10

0.72 ± 0.10

0.54 ± 0.09

0.49 ± 0.09

 

> 1 CL

0.83 ± 0.05*3

0.80 ± 0.07

0.75 ± 0.08

0.71 ± 0.09

0.55 ± 0.09

0.50 ± 0.07

 

UtA PI

0 CL

2.36 ± 0.66

1.87 ± 0.53

1.92 ± 1.46

1.39 ± 0.85*1

0.53 ± 0.09***1,2

0.62 ± 0.16*2

 

1 CL

2.75 ± 0.78

2.29 ± 0.73

1.96 ± 0.69

1.68 ± 0.60

0.90 ± 0.30

0.77 ± 0.27

 

> 1 CL

2.38 ± 0.50**3

2.10 ± 0.46

1.81 ± 0.60

1.60 ± 0.52

0.93 ± 0.29

0.78 ± 0.21

 

MAP (mmHg)

0 CL

80.8 ± 12.1

82.9 ± 9.9

84.0 ± 5.1

86.2 ± 8.7

76.1 ± 8.2

75.7 ± 6.7*1

 

1 CL

80.4 ± 7.0

83.0 ± 8.1

83.9 ± 8.1

82.6 ± 7.5

78.5 ± 8.7

83.0 ± 9.3

 

> 1 CL

79.7 ± 7.2

81.2 ± 7.1

82.7 ± 7.1

81.0 ± 6.5

78.3 ± 6.7

80.5 ± 8.1

 

UmbA RI

0 CL

    

0.68 ± 0.04

0.61 ± 0.05

 

1 CL

    

0.70 ± 0.05

0.61 ± 0.07

 

> 1 CL

    

0.68 ± 0.06

0.63 ± 0.07

 

UmbA PI

0 CL

    

1.09 ± 0.13

0.91 ± 0.11

 

1 CL

    

1.15 ± 0.16

0.94 ± 0.16

 

> 1 CL

    

1.11 ± 0.17

0.98 ± 0.16

 

Placental Weight (gram)

0 CL

      

380 [260;426]

1 CL

      

438 [360;514]

> 1 CL

      

491 [433;563]

  1. Data are presented as (mean ± SD) or median (interquartile range). ***p < 0.001, **p < 0.01, *p < 0.05. 1, statistical difference between 0 CL and 1 CL; 2, statistical difference between 0 CL and > 1 CL; 3, statistical difference between 1 CL and > 1 CL. CL = corpus luteum; GA = gestational age; PV = placental volume; uPVV = utero-placental vascular volume; UtA = uterine artery; RI = resistance index; PI = pulsatility index; MAP = mean arterial pressure; UmbA = umbilical artery