Type of study | Authors/date | Model | Daily dose | Duration | Results |
---|---|---|---|---|---|
Animal studies | Sadoughi et al. 2017 [21] | 42 Wistar female rats were divided into 7 equal groups: control, PCOS control, PCOS treated with aqueous extract of green tea (50 and 100 mg/kg, PCOS treated with catechin (50 and 100 mg/kg) and PCOS treated with clomiphene citrate (1.5 mg/kg, 24 days). | 50,100 mg/kg/day GTE | 24 day | - Serum level of LH, β-estradiol, and testosterone significantly decreased. - Serum level of FSH, progesterone significantly increased. - Number of preantral, antral, preovulatory follicles, and corpus luteum significantly increased. |
Rahbarian et al. 2017 [22] | 24 Wistar female rats were divided into 4 equal groups: control (saline solution), non-treated PCOS (saline solution) and PCOS treated with catechin (50 and 100 mg/kg, 24 days). | 50,100 mg/kg/day GTE | 24 day | -Serum levels of TNF-α, IL-1β, MDA and IL-6 decreased -SOD, CAT, GPX in ovarian tissue significantly increased. | |
Ghafurniya et al. 2015 [23] | 96 Wistar rats were divided into 4 groups: PCOS group, three experimental groups, which were given 50, 100 and 200 mg/Kg BW green tea extract 10 days, intraperitoneally. | 50,100,200 mg/kg/day GTE | 10 day | -LH serum level, body weight and ovarian weight decreased -Insulin resistance and blood glucose decreased -Improved of ovarian function | |
Ghafurniya et al. 2014 [24] | 40 Wistar rats were divided into 5 groups: PCOS rats received no injections (PCOS control), rats received saline (sham), PCOS rats that received of 50 mg/kg of green tea extract (GT-Treated-1), rats that were received intraperitoneal injection 100 mg/kg of green tea extract (GT-Treated-2), rats that were received intraperitoneal injection 200 mg/kg of green tea extract (GT-Treated-3). | 50,100,200 mg/kg/day GTE | 2 weeks | –CRP and IL-6 serum levels reduced. –Improved follicular layers thickness (improving of ovarian function) | |
Human studies | Mombaini et al. 2017 [25] | 45 women with PCOS were randomly allocated into 2 groups receiving GT tablets or placebo | 500-mg/day GTE | 1.5 months | - Significant decrease in BMI, body weight, waist circumference, and body fat percentage. -No effect on the levels of inflammatory factors (IL-6, hs-CRP, TNF-α) |
Tehrani et al. 2017 [26] | 60 Overweight women with PCOS were given GTE | 500 mg/day GTE capsules | 3 months | – Significant decrease in Body weight, FBG, serum insulin and free testosterone. | |
Allahdadian et al. 2015 [27] | 60 overweight or obesity women with PCOS were received GTE tablets and placebo. | 500 mg/day GTE | 3 months | - Significant decrease in BMI and body weight. -Significant decrease in FBS, in sulinand free testosterone levels | |
Chan et al. 2005 [28] | 34 obese Chinese women with PCOS were randomized into either treatment with GTE capsules or placebo. | 1.5 cups of 2% Lung Chen tea (an equivalent of 540 mg EGCG) | 3 months | -No significant effect on body weight, BMI, body fat, total testosterone, SHBG, Free androgen index, DHEA-S, FSH, LH. |