From: Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review
Outcome indicator | Studies | Samples | Heterogeneity | Effect model | RR (95%CI) | P value |
---|---|---|---|---|---|---|
Chemical pregnancy | 3 | 423 | P=0.73 I2=0% | Fixed | 1.59 (1.21-2.09) | <0.01* |
Clinical pregnancy | 10 | 2474 | P=0.19 I2=28% | Fixed | 1.42(1.26-1.60) | <0.01* |
RIF | 6 | 1440 | P=0.03 I2=59% | Random | 1.58 (1.17–2.13) | <0.01* |
NRIF | 4 | 1034 | P=0.97 I2=0% | Random | 1.44 (1.20–1.66) | <0.01* |
Embryo implantation | 4 | 3206 | P<0.01 I2=89% | Random | 1.67 (0.89–3.14) | 0.11 |
Clinical miscarriage | 5 | 517 | P=0.19 I2=35% | Fixed | 0.83(0.57-1.22) | 0.35 |
RIF | 3 | 315 | P=0.39 I2=0% | Fixed | 1.12 (0.71–1.77) | 0.62 |
NRIF | 2 | 202 | P=0.34 I2=0% | Fixed | 0.50 (0.25–1.02) | 0.06 |
Multiple pregnancy | 8 | 642 | P=0.25 I2=23% | Fixed | 1.10(0.83-1.47) | 0.05 |
RIF | 6 | 440 | P=0.43 I2=0% | Fixed | 1.47 (1.01–2.16) | 0.05 |
NRIF | 2 | 202 | P=0.19 I2=35% | Fixed | 0.72 ( 0.45–1.14) | 0.16 |
Live birth | 2 | 531 | P=0.91 I2=0% | Fixed | 1.99 (1.47–2.71) | <0.01* |