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Table 4 Clinical, endocrine, and metabolic features of PCOS and control women according to presence or absence of Apa-I SNP

From: Apa-I polymorphism in VDR gene is related to metabolic syndrome in polycystic ovary syndrome: a cross-sectional study

Variable

PCOS (n = 190)

Controls (n = 100)

 

CC (41)

CA + AA (149)

CC (16)

CA + AA (84)

p gen

WC (cm)#

91.97 ± 15.45

88.56 ± 14.96

81.42 ± 13.08

77.41 ± 11.20

0.149

SBP (mmHg)#

127.02 ± 19.79 a

119.49 ± 13.69 b

113.83 ± 11.35 a

108.60 ± 13.10 b

0.009

DBP (mmHg)#

81.30 ± 13.46

77.21 ± 10.84

72.77 ± 10.17

70.41 ± 9.24

0.079

Glucose (mg/dL)

87.88 ± 13.18

89.14 ± 15.92

90.47 ± 7.13

88.08 ± 7.65

0.805

Insulin (μUI/mL)#

20.28 ± 12.85

22.41 ± 21.27

11.64 ± 5.78

12.03 ± 6.71

0.846

HOMA-IR#

4.45 ± 3.07

5.12 ± 5.86

2.56 ± 1.45

2.50 ± 1.60

0.654

TC (mg/dL)

180.95 ± 37.35 a

172.73 ± 38.55 b

183.80 ± 36.87 a

167.26 ± 28.76 b

0.040

HDL-c (mg/dL)#

46.12 ± 10.73

49.59 ± 10.86

53.73 ± 11.21

52.65 ± 12.55

0.529

LDL-c (mg/dL)

111.05 ± 31.97 a

102.52 ± 31.69 b

111.99 ± 32.73 a

99.56 ± 24.48 b

0.038

Trig (mg/dL)#

118.90 ± 99.18

104.29 ± 62.18

90.40 ± 55.15

75.28 ± 41.89

0.149

25(OH)D (ng/mL)

19.41 ± 5.23

22.12 ± 8.17

21.31 ± 6.15

21.52 ± 7.16

0.399

  1. WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure, HOMA homeostasis model assessment index, TC total cholesterol, HDL-c high-density lipoprotein cholesterol, LDL-c low-density lipoprotein cholesterol, Trig triglycerides, 25(OH)D 25-hydroxyvitamin D
  2. Values are expressed as means ± SD (two-way ANOVA). Different superscript letters indicate statistical difference for comparisons between genotypes, grouped by the absence or presence of the polymorphic allele, in PCOS and control groups. # p < 0.005 for comparisons between PCOS (CC and CA + AA) and control (CC and CA + AA) groups
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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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