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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: In vivo monitoring of fetoplacental Vegfr2 gene activity in a murine pregnancy model using a Vegfr2-luc reporter gene and bioluminescent imaging

Figure 2

In vivo bioluminescent imaging of fetoplacental Vegfr2 activity. Quantitative differences in light emissions (p/s) were found during the seven day imaging period (P < 0.05). (a) Comparing gestational day (GD) 12 to 18, total light emissions (p/s) increased by approximately 23-fold (P = 0.0006). The insert illustrates the increase in maternal body weight (P = 0.0008) occurring during this period, indicating fetoplacental growth. (b) Light emissions corrected for fetoplacental mass (p/s/g) also increased by approximately 9-fold (P < 0.0001) during this time. (c) Additionally, the images demonstrate qualitative monitoring of fetoplacental Vegfr2 gene activity in a complete set of images chosen from a representative animal.a,b,cmeans without a common superscript differ (P ≤ 0.05).

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