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Figure 2 | Reproductive Biology and Endocrinology

Figure 2

From: A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down's syndrome pregnancies

Figure 2

The structure of LHCGR mRNA and expression in chorionic villous samples (CVS) from DS and other trisomic pregnancies. a) the organization of exons 1–11 in full-length (FL) LHCGR mRNA (open boxes) and possible alternatively spliced isoforms 1–7 [41-43]. The sequences deleted from the isoforms are indicated by closed boxes. Regions of mRNA encoding the extracellular domain (ECD), transmembrane (TM) domain, the hinge region and the intra-cellular domain (ICD) are shown. The regions of cDNA (exons 1–5 and exon 11) amplified by Q-PCR are indicated by bidirectional arrows. b) chorionic LHCGR mRNA expression (exons 1–5) in control (N = 24), T21 [DS, N = 23], T18 (N = 8) and T13 (N = 3) pregnancies; c) chorionic LHCGR mRNA expression (exon 11) in control (N = 15) and T21 (N = 18) pregnancies. The median values and 95% confidence ranges of RNA expression in each pregnancy condition are shown; N = number of patient samples analyzed. *P < 0.05, **P < 0.01.

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